Version 5.4
Homo sapiens Protein: WDR4
Summary
InnateDB Protein IDBP-4539.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR4
Protein Name WD repeat domain 4
Synonyms TRM82; TRMT82;
Species Homo sapiens
Ensembl Protein ENSP00000328671
InnateDB Gene IDBG-4537 (WDR4)
Protein Structure
UniProt Annotation
Function Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. {ECO:0000255HAMAP-Rule:MF_03056, ECO:0000269PubMed:12403464}.
Subcellular Localization Nucleus {ECO:0000255HAMAP-Rule:MF_03056, ECO:0000269PubMed:15861136}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 38 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008176 tRNA (guanine-N7-)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0030488 tRNA methylation
GO:0036265 RNA (guanine-N7)-methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57081
PhosphoSite PhosphoSite-P57081
TrEMBL
UniProt Splice Variant
Entrez Gene 10785
UniGene Hs.741517
RefSeq NP_387510
HUGO HGNC:12756
OMIM 605924
CCDS CCDS13691
HPRD 09330
IMGT
EMBL AB039887 AJ243912 AJ243913 AK056343 AK292923 AK298015 AK315008 AP001629 BC001074 BC006341 CH471079
GenPept AAH01074 AAH06341 BAB13726 BAF85612 BAG37500 BAG51684 BAG60319 CAB93144 CAB93145 EAX09528 EAX09529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca