InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EAPP

Summary

InnateDB Protein

IDBP-4545.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EAPP

Protein Name

E2F-associated phosphoprotein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000250454

InnateDB Gene

IDBG-4543 (EAPP)

Protein Structure

UniProt Annotation

Function

May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269PubMed:15716352}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts. {ECO:0000269PubMed:15716352, ECO:0000269PubMed:15820313}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter