InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: H2AFY

Summary

InnateDB Protein

IDBP-45487.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2AFY

Protein Name

H2A histone family, member Y

Synonyms

H2A.y; H2A/y; H2AF12M; H2AFJ; MACROH2A1.1; macroH2A1.2; mH2A1;

Species

Homo sapiens

Ensembl Protein

ENSP00000310169

InnateDB Gene

IDBG-45483 (H2AFY)

Protein Structure

UniProt Annotation

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP- ribose, and may be involved in ADP-ribose-mediated chromatin modulation. {ECO:0000269PubMed:12718888, ECO:0000269PubMed:15621527, ECO:0000269PubMed:15897469, ECO:0000269PubMed:16107708, ECO:0000269PubMed:16428466}.

Subcellular Localization

Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9714746}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	48 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000182	rDNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0010385	double-stranded methylated DNA binding
GO:0019901	protein kinase binding
GO:0030291	protein serine/threonine kinase inhibitor activity
GO:0031490	chromatin DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006334	nucleosome assembly
GO:0007549	dosage compensation
GO:0016568	chromatin modification
GO:0033128	negative regulation of histone phosphorylation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0071169	establishment of protein localization to chromatin
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:1902750	negative regulation of cell cycle G2/M phase transition

Cellular Component

GO:0000786	nucleosome
GO:0000790	nuclear chromatin
GO:0001739	sex chromatin
GO:0001740	Barr body
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0035098	ESC/E(Z) complex
GO:0070062	extracellular vesicular exosome