Version 5.4
Homo sapiens Protein: TMBIM4
Summary
InnateDB Protein IDBP-45513.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMBIM4
Protein Name transmembrane BAX inhibitor motif containing 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350965
InnateDB Gene IDBG-45509 (TMBIM4)
Protein Structure
UniProt Annotation
Function Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. {ECO:0000269PubMed:17319741, ECO:0000269PubMed:19553469}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:17319741, ECO:0000269PubMed:22418439}; Multi- pass membrane protein {ECO:0000269PubMed:17319741, ECO:0000269PubMed:22418439}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0050848 regulation of calcium-mediated signaling
Cellular Component
GO:0000139 Golgi membrane
GO:0005795 Golgi stack
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006214 Bax inhibitor 1-related
PFAM PF01027
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HC24
PhosphoSite PhosphoSite-Q9HC24
TrEMBL G3V1R8
UniProt Splice Variant
Entrez Gene 51643
UniGene Hs.622733
RefSeq NP_057140
HUGO HGNC:24257
OMIM
CCDS CCDS41805
HPRD
IMGT
EMBL AC078927 AF113127 AF151877 AF182041 AK075069 BC020613 CH471054
GenPept AAD34114 AAF14868 AAG16898 BAC11384 EAW97160

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca