InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO31

Summary

InnateDB Protein

IDBP-45595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO31

Protein Name

F-box protein 31

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000310841

InnateDB Gene

IDBG-45593 (FBXO31)

Protein Structure

UniProt Annotation

Function

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. {ECO:0000269PubMed:16357137, ECO:0000269PubMed:19412162}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. {ECO:0000269PubMed:16357137}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030332	cyclin binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0008054	cyclin catabolic process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031571	mitotic G1 DNA damage checkpoint