Version 5.4
Homo sapiens Protein: PIK3IP1
Summary
InnateDB Protein IDBP-4563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3IP1
Protein Name phosphoinositide-3-kinase interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000215912
InnateDB Gene IDBG-4561 (PIK3IP1)
Protein Structure
UniProt Annotation
Function Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:19088825}; Single-pass type I membrane protein {ECO:0000269PubMed:19088825}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding
Biological Process
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000001 Kringle
IPR013806 Kringle-like fold
PFAM PF00051
PRINTS
PIRSF
SMART SM00130
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96FE7
PhosphoSite PhosphoSite-Q96FE7
TrEMBL A0A024R1M3
UniProt Splice Variant
Entrez Gene 113791
UniGene Hs.26670
RefSeq NP_443112
HUGO HGNC:24942
OMIM
CCDS CCDS13893
HPRD 17518
IMGT
EMBL AC002073 AF528079 AF528080 AK074688 AK299397 BC011049 BC041903 CH471095 CR456340 GU135609
GenPept AAB54054 AAH11049 AAH41903 AAO33762 AAO33763 ACZ26468 BAC11140 BAG61381 CAG30226 EAW59960 EAW59962 EAW59964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca