InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP1LC3B

Summary

InnateDB Protein

IDBP-45640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP1LC3B

Protein Name

microtubule-associated protein 1 light chain 3 beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000268607

InnateDB Gene

IDBG-45638 (MAP1LC3B)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. {ECO:0000269PubMed:20418806, ECO:0000269PubMed:23209295, ECO:0000269PubMed:24089205}.

Subcellular Localization

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. {ECO:0000269PubMed:12740394}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 154 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	154 [view]
Protein-Protein	152 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006914	autophagy

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005874	microtubule
GO:0005930	axoneme
GO:0012505	endomembrane system
GO:0031090	organelle membrane
GO:0031410	cytoplasmic vesicle