Version 5.4
Homo sapiens Protein: CADM2
Summary
InnateDB Protein IDBP-45650.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CADM2
Protein Name cell adhesion molecule 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373200
InnateDB Gene IDBG-45644 (CADM2)
Protein Structure
UniProt Annotation
Function Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. {ECO:0000269PubMed:17967169}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:17967169}; Single-pass type I membrane protein {ECO:0000269PubMed:17967169}. Cell junction, synapse {ECO:0000269PubMed:17967169}. Cell projection, axon {ECO:0000269PubMed:17967169}. Note=Found in the axoplasm of myelinated axons.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR003585 Neurexin/syndecan/glycophorin C
IPR003597 Immunoglobulin C1-set
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF07654
PF07679
PF07686
PF00047
PF08205
PRINTS
PIRSF
SMART SM00294
SM00407
SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N3J6
PhosphoSite PhosphoSite-Q8N3J6
TrEMBL G3XHN4
UniProt Splice Variant
Entrez Gene 253559
UniGene Hs.735502
RefSeq NP_001243434
HUGO HGNC:29849
OMIM 609938
CCDS CCDS54613
HPRD 11046
IMGT
EMBL AB646739 AB646740 AB646741 AB646742 AB646743 AF538973 AL833049 AL834270 BC105999
GenPept AAI06000 AAN16368 BAK93302 BAK93303 BAK93304 BAK93305 BAK93306 CAD38945 CAH56314

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca