InnateDB Protein
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IDBP-45739.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NEUROD2
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Protein Name
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neurogenic differentiation 2
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Synonyms
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bHLHa1; NDRF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306754
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InnateDB Gene
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IDBG-45737 (NEUROD2)
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Protein Structure
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Function |
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0001228
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RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003714
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transcription corepressor activity
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GO:0005515
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protein binding
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GO:0046982
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protein heterodimerization activity
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GO:0046983
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protein dimerization activity
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GO:0070888
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E-box binding
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Biological Process |
GO:0001662
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behavioral fear response
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GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0007399
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nervous system development
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GO:0008306
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associative learning
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GO:0016567
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protein ubiquitination
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GO:0021695
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cerebellar cortex development
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GO:0031915
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positive regulation of synaptic plasticity
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GO:0045666
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positive regulation of neuron differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048666
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neuron development
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GO:0050850
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positive regulation of calcium-mediated signaling
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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GO:0071257
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cellular response to electrical stimulus
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GO:0071277
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cellular response to calcium ion
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GO:0090129
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positive regulation of synapse maturation
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GO:2000297
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negative regulation of synapse maturation
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637
Transcription factor, basic helix-loop-helix, NeuroD
IPR022575
Neurogenic differentiation factor, domain of unknown function
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PFAM |
PF00010
PF12533
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PRINTS |
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PIRSF |
PIRSF015618
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q15784
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PhosphoSite |
PhosphoSite-Q15784
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4761
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UniGene |
Hs.322431
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RefSeq |
NP_006151
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HUGO |
HGNC:7763
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OMIM |
601725
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CCDS |
CCDS11338
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HPRD |
03429
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IMGT |
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EMBL |
AB021742
BC022481
U58681
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GenPept |
AAC26058
AAH22481
BAA77569
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