Version 5.4
Homo sapiens Protein: HTR1F
Summary
InnateDB Protein IDBP-45822.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR1F
Protein Name 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms 5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77;
Species Homo sapiens
Ensembl Protein ENSP00000322924
InnateDB Gene IDBG-45820 (HTR1F)
Protein Structure
UniProt Annotation
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269PubMed:21422162, ECO:0000269PubMed:8380639, ECO:0000269PubMed:8384716}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:8380639, ECO:0000269PubMed:8384716}; Multi-pass membrane protein {ECO:0000269PubMed:8380639, ECO:0000269PubMed:8384716}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
GO:0051378 serotonin binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007268 synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000450 5-Hydroxytryptamine 1F receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR00515
PR01101
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30939
PhosphoSite PhosphoSite-P30939
TrEMBL Q9P2Q4
UniProt Splice Variant
Entrez Gene 3355
UniGene Hs.611162
RefSeq NP_000857
HUGO HGNC:5292
OMIM 182134
CCDS CCDS2920
HPRD 01637
IMGT
EMBL AB037533 AC119733 AF498981 BC069125 L04962 L05597
GenPept AAA36605 AAA36646 AAH69125 AAM21128 BAA90453

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca