Version 5.4
Homo sapiens Protein: SERPINB10
Summary
InnateDB Protein IDBP-4583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB10
Protein Name serpin peptidase inhibitor, clade B (ovalbumin), member 10
Synonyms PI-10; PI10;
Species Homo sapiens
Ensembl Protein ENSP00000238508
InnateDB Gene IDBG-402073 (SERPINB10)
Protein Structure
UniProt Annotation
Function Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus. {ECO:0000269PubMed:10871600, ECO:0000269PubMed:7592909}.
Subcellular Localization Nucleus. Cytoplasm. Note=Mostly found in the nucleus.
Disease Associations
Tissue Specificity Expressed specifically in myeloid cells and the bone marrow. {ECO:0000269PubMed:20433722, ECO:0000269PubMed:7592909}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48595
PhosphoSite PhosphoSite-P48595
TrEMBL
UniProt Splice Variant
Entrez Gene 5273
UniGene Hs.158339
RefSeq
HUGO HGNC:8942
OMIM 602058
CCDS CCDS11990
HPRD 03635
IMGT
EMBL BC096217 BC096219 BC096220 U35459
GenPept AAC50282 AAH96217 AAH96219 AAH96220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca