InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PKNOX1

Summary

InnateDB Protein

IDBP-4586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKNOX1

Protein Name

PBX/knotted 1 homeobox 1

Synonyms

pkonx1c; PREP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000291547

InnateDB Gene

IDBG-4584 (PKNOX1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow. {ECO:0000269PubMed:15468914, ECO:0000269PubMed:9143494}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030097	hemopoiesis
GO:0030217	T cell differentiation
GO:0030218	erythrocyte differentiation
GO:0043010	camera-type eye development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter