InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC7A5

Summary

InnateDB Protein

IDBP-45908.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A5

Protein Name

solute carrier family 7 (amino acid transporter light chain, L system), member 5

Synonyms

4F2LC; CD98; D16S469E; E16; hLAT1; LAT1; MPE16;

Species

Homo sapiens

Ensembl Protein

ENSP00000261622

InnateDB Gene

IDBG-45906 (SLC7A5)

Protein Structure

UniProt Annotation

Function

Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. {ECO:0000269PubMed:10049700, ECO:0000269PubMed:10391915, ECO:0000269PubMed:10574970, ECO:0000269PubMed:11311135, ECO:0000269PubMed:11389679, ECO:0000269PubMed:11557028, ECO:0000269PubMed:11564694, ECO:0000269PubMed:11742812, ECO:0000269PubMed:12117417, ECO:0000269PubMed:12225859, ECO:0000269PubMed:15769744, ECO:0000269PubMed:16496379, ECO:0000269PubMed:18262359, ECO:0000269PubMed:9751058}.

Subcellular Localization

Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2. {ECO:0000269PubMed:10049700, ECO:0000269PubMed:10072483, ECO:0000269PubMed:11389679, ECO:0000269PubMed:11557028, ECO:0000269PubMed:11742812, ECO:0000269PubMed:12824232, ECO:0000269PubMed:1597461, ECO:0000269PubMed:16027961, ECO:0000269PubMed:16496379}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity
GO:0015175	neutral amino acid transmembrane transporter activity
GO:0015179	L-amino acid transmembrane transporter activity
GO:0042605	peptide antigen binding

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006520	cellular amino acid metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0007399	nervous system development
GO:0007596	blood coagulation
GO:0015804	neutral amino acid transport
GO:0015807	L-amino acid transport
GO:0030154	cell differentiation
GO:0050900	leukocyte migration
GO:0055085	transmembrane transport
GO:1902475	L-alpha-amino acid transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome