InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRFN3

Summary

InnateDB Protein

IDBP-46075.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRFN3

Protein Name

leucine rich repeat and fibronectin type III domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000246529

InnateDB Gene

IDBG-46073 (LRFN3)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM