InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FIGF

Summary

InnateDB Protein

IDBP-46125.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FIGF

Protein Name

c-fos induced growth factor (vascular endothelial growth factor D)

Synonyms

VEGF-D; VEGFD;

Species

Homo sapiens

Ensembl Protein

ENSP00000297904

InnateDB Gene

IDBG-46123 (FIGF)

Protein Structure

UniProt Annotation

Function

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269PubMed:21148085}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0042803	protein homodimerization activity
GO:0043185	vascular endothelial growth factor receptor 3 binding

Biological Process

GO:0001525	angiogenesis
GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0030168	platelet activation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0060754	positive regulation of mast cell chemotaxis