InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFPM1

Summary

InnateDB Protein

IDBP-46139.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFPM1

Protein Name

zinc finger protein, multitype 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326630

InnateDB Gene

IDBG-46137 (ZFPM1)

Protein Structure

UniProt Annotation

Function

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen. {ECO:0000269PubMed:12483298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002295	T-helper cell lineage commitment
GO:0003151	outflow tract morphogenesis
GO:0003181	atrioventricular valve morphogenesis
GO:0003192	mitral valve formation
GO:0003195	tricuspid valve formation
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0010724	regulation of definitive erythrocyte differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030220	platelet formation
GO:0030851	granulocyte differentiation
GO:0032091	negative regulation of protein binding
GO:0032642	regulation of chemokine production
GO:0035162	embryonic hemopoiesis
GO:0035855	megakaryocyte development
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045403	negative regulation of interleukin-4 biosynthetic process
GO:0045599	negative regulation of fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048872	homeostasis of number of cells
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060318	definitive erythrocyte differentiation
GO:0060319	primitive erythrocyte differentiation
GO:0060377	negative regulation of mast cell differentiation
GO:0060412	ventricular septum morphogenesis
GO:0060413	atrial septum morphogenesis
GO:0071733	transcriptional activation by promoter-enhancer looping