InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIR

Summary

InnateDB Protein

IDBP-46193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIR

Protein Name

pirin (iron-binding nuclear protein)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369786

InnateDB Gene

IDBG-46191 (PIR)

Protein Structure

UniProt Annotation

Function

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269PubMed:17288615, ECO:0000269PubMed:20010624, ECO:0000269PubMed:20711196, ECO:0000269PubMed:23716661}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.

Disease Associations

Tissue Specificity

Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. {ECO:0000269PubMed:20089166, ECO:0000269PubMed:9079676}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0008127	quercetin 2,3-dioxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030099	myeloid cell differentiation
GO:0030224	monocyte differentiation
GO:0055114	oxidation-reduction process