Version 5.4
Homo sapiens Protein: ENPP6
Summary
InnateDB Protein IDBP-46203.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENPP6
Protein Name ectonucleotide pyrophosphatase/phosphodiesterase 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296741
InnateDB Gene IDBG-46199 (ENPP6)
Protein Structure
UniProt Annotation
Function Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid. {ECO:0000250, ECO:0000269PubMed:15788404}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu.
Disease Associations
Tissue Specificity Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). {ECO:0000269PubMed:15788404}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
GO:0047390 glycerophosphocholine cholinephosphodiesterase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0019695 choline metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain
PFAM PF01663
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UWR7
PhosphoSite PhosphoSite-Q6UWR7
TrEMBL D6R9P1
UniProt Splice Variant
Entrez Gene 133121
UniGene Hs.297814
RefSeq NP_699174
HUGO HGNC:23409
OMIM
CCDS CCDS3834
HPRD 16863
IMGT
EMBL AC079080 AC107222 AK057370 AY358676 BC035035
GenPept AAH35035 AAQ89039 AAY40908 BAB71455

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca