InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHFRL1

Summary

InnateDB Protein

IDBP-46237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHFRL1

Protein Name

dihydrofolate reductase-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000319170

InnateDB Gene

IDBG-46235 (DHFRL1)

Protein Structure

UniProt Annotation

Function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269PubMed:21876184, ECO:0000269PubMed:21876188}.

Subcellular Localization

Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Expressed in numerous cell lines. {ECO:0000269PubMed:21876184}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0004146	dihydrofolate reductase activity
GO:0050661	NADP binding

Biological Process

GO:0006545	glycine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0009165	nucleotide biosynthetic process
GO:0046105	thymidine biosynthetic process
GO:0046653	tetrahydrofolate metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0055114	oxidation-reduction process