InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUP107

Summary

InnateDB Protein

IDBP-46278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP107

Protein Name

nucleoporin 107kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000229179

InnateDB Gene

IDBG-46276 (NUP107)

Protein Structure

UniProt Annotation

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. {ECO:0000269PubMed:12552102, ECO:0000269PubMed:15229283}.

Subcellular Localization

Nucleus membrane. Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure. During mitosis, localizes to the kinetochores. Dissociates from the dissasembled NPC structure late during prophase of mitosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	43 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006406	mRNA export from nucleus
GO:0006810	transport
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0051292	nuclear pore complex assembly
GO:0055085	transmembrane transport

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0031080	nuclear pore outer ring
GO:0031965	nuclear membrane
GO:0034399	nuclear periphery