InnateDB Protein
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IDBP-46472.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPAPDC2
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Protein Name
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phosphatidic acid phosphatase type 2 domain containing 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371307
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InnateDB Gene
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IDBG-46470 (PPAPDC2)
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Protein Structure
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Function |
Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. {ECO:0000269PubMed:16464866}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain. {ECO:0000269PubMed:16464866}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000326
Phosphatidic acid phosphatase type 2/haloperoxidase
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PFAM |
PF01569
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PRINTS |
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PIRSF |
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SMART |
SM00014
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IY26
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PhosphoSite |
PhosphoSite-Q8IY26
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
403313
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UniGene |
Hs.741666
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RefSeq |
NP_982278
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HUGO |
HGNC:23682
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OMIM |
611666
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CCDS |
CCDS34981
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HPRD |
17397
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IMGT |
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EMBL |
AK074672
AK128369
AL136231
BC038108
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GenPept |
AAH38108
BAG54667
CAI41266
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