InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACE2

Summary

InnateDB Protein

IDBP-46538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACE2

Protein Name

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000252519

InnateDB Gene

IDBG-46534 (ACE2)

Protein Structure

UniProt Annotation

Function

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. {ECO:0000269PubMed:10924499, ECO:0000269PubMed:10969042, ECO:0000269PubMed:14647384, ECO:0000269PubMed:24227843}.

Subcellular Localization

Processed angiotensin-converting enzyme 2: Secreted.Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. {ECO:0000269PubMed:10924499, ECO:0000269PubMed:10969042, ECO:0000269PubMed:12459472, ECO:0000269PubMed:15141377, ECO:0000269PubMed:15231706, ECO:0000269PubMed:15671045}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001948	glycoprotein binding
GO:0004175	endopeptidase activity
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008241	peptidyl-dipeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0002003	angiotensin maturation
GO:0002005	angiotensin catabolic process in blood
GO:0003051	angiotensin-mediated drinking behavior
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006508	proteolysis
GO:0009615	response to virus
GO:0019229	regulation of vasoconstriction
GO:0032800	receptor biosynthetic process
GO:0042127	regulation of cell proliferation
GO:0042312	regulation of vasodilation
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046718	viral entry into host cell
GO:0046813	receptor-mediated virion attachment to host cell
GO:0050727	regulation of inflammatory response
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome