Homo sapiens Protein: RTN4RL2
Summary
InnateDB Protein IDBP-46632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN4RL2
Protein Name reticulon 4 receptor-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000335397
InnateDB Gene IDBG-46630 (RTN4RL2)
Protein Structure
UniProt Annotation
Function May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. {ECO:0000303PubMed:14664809}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12694398}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:12694398}. Note=Localized to the surface of neurons, including axons.
Disease Associations
Tissue Specificity Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid. {ECO:0000269PubMed:12694398, ECO:0000269PubMed:14664809}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0031103 axon regeneration
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86UN3
PhosphoSite PhosphoSite-Q86UN3
TrEMBL
UniProt Splice Variant
Entrez Gene 349667
UniGene Hs.603388
RefSeq NP_848665
HUGO HGNC:23053
OMIM 610462
CCDS CCDS7957
HPRD 11524
IMGT
EMBL AF532858 AP002893 AY250221 BC113673 BC117276 BK001302 DQ864979
GenPept AAI13674 AAI17277 AAP21835 AAP82838 ABI23432 DAA01385