Version 5.4
Homo sapiens Protein: GSDMA
Summary
InnateDB Protein IDBP-46751.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSDMA
Protein Name gasdermin A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000301659
InnateDB Gene IDBG-46749 (GSDMA)
Protein Structure
UniProt Annotation
Function Induces apoptosis. {ECO:0000269PubMed:17471240}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:17471240}.
Disease Associations
Tissue Specificity Expressed predominantly in the gastrointestinal tract and in the skin at a lower level. Also detected in mammary gland. Detected in mucus-secreting pit cells of the gastric epithelium. Not expressed in gastric cancer cells. {ECO:0000269PubMed:10967128, ECO:0000269PubMed:17471240}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0045087 innate immune response
Cellular Component
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007677 Gasdermin
PFAM PF04598
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96QA5
PhosphoSite PhosphoSite-Q96QA5
TrEMBL J3KRG2
UniProt Splice Variant
Entrez Gene 284110
UniGene Hs.448873
RefSeq NP_835465
HUGO HGNC:13311
OMIM 611218
CCDS CCDS45669
HPRD 17081
IMGT
EMBL AB093591 AC090844 AF307953 AK096439 BC109197
GenPept AAI09198 AAL14426 BAC04790 BAC75636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca