Version 5.4
Homo sapiens Protein: TMX3
Summary
InnateDB Protein IDBP-4698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMX3
Protein Name thioredoxin-related transmembrane protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000299608
InnateDB Gene IDBG-4696 (TMX3)
Protein Structure
UniProt Annotation
Function Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. {ECO:0000269PubMed:15623505}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15623505}; Single-pass membrane protein {ECO:0000269PubMed:15623505}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye and muscle. {ECO:0000269PubMed:15623505}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006457 protein folding
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001393 Calsequestrin
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF01216
PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS PR00312
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JJ7
PhosphoSite PhosphoSite-Q96JJ7
TrEMBL
UniProt Splice Variant
Entrez Gene 54495
UniGene Hs.599540
RefSeq NP_061895
HUGO HGNC:24718
OMIM
CCDS CCDS32840
HPRD 15591
IMGT
EMBL AB058733 AK000800 AK122715 BC032325 BC093792 BC093794 BX647846
GenPept AAH32325 AAH93792 AAH93794 BAA91381 BAB47459 BAG53687

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca