InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LYZ

Summary

InnateDB Protein

IDBP-46989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYZ

Protein Name

lysozyme

Synonyms

LZM;

Species

Homo sapiens

Ensembl Protein

ENSP00000261267

InnateDB Gene

IDBG-46987 (LYZ)

Protein Structure

UniProt Annotation

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents.

Subcellular Localization

Secreted.

Disease Associations

Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. {ECO:0000269PubMed:8464497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003796	lysozyme activity
GO:0042802	identical protein binding

Biological Process

GO:0001895	retina homeostasis
GO:0006954	inflammatory response
GO:0016998	cell wall macromolecule catabolic process
GO:0019835	cytolysis
GO:0042742	defense response to bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000974 Glycoside hydrolase, family 22, lysozyme
IPR001916 Glycoside hydrolase, family 22
IPR008258 Lytic transglycosylase-like SLT domain
IPR023346 Lysozyme-like domain

PFAM

PF00062
PF01464
PF13406

PRINTS

PR00137
PR00135

PIRSF

SMART

SM00263

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt