InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH15

Summary

InnateDB Protein

IDBP-47216.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH15

Protein Name

cadherin 15, type 1, M-cadherin (myotubule)

Synonyms

CDH14; CDH3; CDHM; MCAD; MRD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000289746

InnateDB Gene

IDBG-47214 (CDH15)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).Mental retardation, autosomal dominant 3 (MRD3) [MIM:612580]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:19012874}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in the brain and cerebellum. {ECO:0000269PubMed:19012874}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0042692	muscle cell differentiation
GO:0045216	cell-cell junction organization
GO:0051149	positive regulation of muscle cell differentiation