Version 5.4
Homo sapiens Protein: BEST3
Summary
InnateDB Protein IDBP-47257.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BEST3
Protein Name bestrophin 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332413
InnateDB Gene IDBG-47253 (BEST3)
Protein Structure
UniProt Annotation
Function Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269PubMed:12907679}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina. {ECO:0000269PubMed:12032738}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005254 chloride channel activity
Biological Process
GO:0008150 biological_process
GO:0015698 inorganic anion transport
GO:0043271 negative regulation of ion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
Protein Structure and Domains
PDB ID
InterPro IPR021134 Bestrophin/UPF0187
PFAM PF01062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N1M1
PhosphoSite PhosphoSite-Q8N1M1
TrEMBL F8VVZ2
UniProt Splice Variant
Entrez Gene 144453
UniGene Hs.280782
RefSeq NP_116124
HUGO HGNC:17105
OMIM 607337
CCDS CCDS8992
HPRD 17484
IMGT
EMBL AC016153 AC018921 AC025263 AF440758 AK096459 AY515706 BC006440
GenPept AAH06440 AAM76997 AAR99656 BAC04797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca