InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNPDA1

Summary

InnateDB Protein

IDBP-473358.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNPDA1

Protein Name

glucosamine-6-phosphate deaminase 1

Synonyms

GNP1; GNPDA; GNPI; GPI; HLN;

Species

Homo sapiens

Ensembl Protein

ENSP00000423674

InnateDB Gene

IDBG-51150 (GNPDA1)

Protein Structure

UniProt Annotation

Function

Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004342	glucosamine-6-phosphate deaminase activity
GO:0016787	hydrolase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006043	glucosamine catabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0007338	single fertilization

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004547 Glucosamine-6-phosphate isomerase
IPR006148 Glucosamine/galactosamine-6-phosphate isomerase

PFAM

PF01182

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-P46926

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AC005740 AF029914 AF035804 AF035805 AF035806 AF035807 AF035808 AF035809 AF048826 AJ002231 BC012853 BC020769 BC022322 CH471062 D31766

GenPept

AAB84217 AAB88748 AAC05123 AAC62119 AAH12853 AAH20769 AAH22322 BAA06544 CAA05259 EAW61890 EAW61891 EAW61892 EAW61893

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca