Version 5.4
Homo sapiens Protein: DCUN1D2
Summary
InnateDB Protein IDBP-473400.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCUN1D2
Protein Name DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000417706
InnateDB Gene IDBG-53314 (DCUN1D2)
Protein Structure
UniProt Annotation
Function Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. {ECO:0000269PubMed:23201271}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR005176 Potentiating neddylation domain
IPR009060 UBA-like
PFAM PF03556
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PH85
PhosphoSite PhosphoSite-Q6PH85
TrEMBL C9JRE2
UniProt Splice Variant
Entrez Gene 55208
UniGene Hs.743371
RefSeq NP_001014305
HUGO HGNC:20328
OMIM
CCDS CCDS32013
HPRD 12614
IMGT
EMBL AK000099 AK001566 AL160251 AL442125 BC056669
GenPept AAH56669 BAA90944 BAA91760 CAI39428 CAI39429 CAI39777 CAI39778 CAI39779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca