InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CREBRF

Summary

InnateDB Protein

IDBP-473462.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREBRF

Protein Name

chromosome 5 open reading frame 41

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000428290

InnateDB Gene

IDBG-57934 (CREBRF)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. {ECO:0000269PubMed:18391022}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18391022}. Note=Colocalizes with CREB3 in nuclear foci.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0006986	response to unfolded protein
GO:0032388	positive regulation of intracellular transport
GO:0034976	response to endoplasmic reticulum stress
GO:0045732	positive regulation of protein catabolic process
GO:0051222	positive regulation of protein transport
GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response