InnateDB Protein
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IDBP-47348.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RAB3IP
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Protein Name
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RAB3A interacting protein (rabin3)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000247833
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InnateDB Gene
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IDBG-47346 (RAB3IP)
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Protein Structure
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Function |
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. {ECO:0000269PubMed:12221131, ECO:0000269PubMed:20890297, ECO:0000269PubMed:20937701}.
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Subcellular Localization |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver. {ECO:0000269PubMed:12007189, ECO:0000269PubMed:12221131}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0017112
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Rab guanyl-nucleotide exchange factor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009449
GDPGTP exchange factor Sec2p
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PFAM |
PF06428
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96QF0
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PhosphoSite |
PhosphoSite-Q96QF0
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TrEMBL |
F8VNX9
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UniProt Splice Variant |
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Entrez Gene |
117177
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UniGene |
Hs.609823
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RefSeq |
NP_071901
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HUGO |
HGNC:16508
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OMIM |
608686
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CCDS |
CCDS8995
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HPRD |
10565
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IMGT |
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EMBL |
AC025263
AJ312896
AJ312897
AJ312898
AJ312899
AJ312900
AJ312901
AK026201
AK027566
AK027671
BC015548
BC059358
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GenPept |
AAH15548
AAH59358
BAB15391
BAB55202
BAB55283
CAC59835
CAC59836
CAC59837
CAC59838
CAC59839
CAC59840
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