InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPARGC1A

Summary

InnateDB Protein

IDBP-473519.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARGC1A

Protein Name

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Synonyms

LEM6; PGC-1(alpha); PGC-1v; PGC1; PGC1A; PPARGC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000421632

InnateDB Gene

IDBG-11756 (PPARGC1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	79 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0050681	androgen receptor binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001678	cellular glucose homeostasis
GO:0006094	gluconeogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0006461	protein complex assembly
GO:0007005	mitochondrion organization
GO:0007586	digestion
GO:0008380	RNA splicing
GO:0010822	positive regulation of mitochondrion organization
GO:0010941	regulation of cell death
GO:0014850	response to muscle activity
GO:0019395	fatty acid oxidation
GO:0022904	respiratory electron transport chain
GO:0030521	androgen receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0034599	cellular response to oxidative stress
GO:0035066	positive regulation of histone acetylation
GO:0042594	response to starvation
GO:0042752	regulation of circadian rhythm
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045333	cellular respiration
GO:0045722	positive regulation of gluconeogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046321	positive regulation of fatty acid oxidation
GO:0050821	protein stabilization
GO:0050873	brown fat cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070997	neuron death
GO:2000507	positive regulation of energy homeostasis
GO:2001171	positive regulation of ATP biosynthetic process