InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASA4B

Summary

InnateDB Protein

IDBP-473792.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASA4B

Protein Name

RAS p21 protein activator 4B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417895

InnateDB Gene

IDBG-33681 (RASA4B)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00779
PF00169
PF00616

PRINTS

PR00360
PR00402

PIRSF

SMART

SM00239
SM00107
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt