InnateDB Protein
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IDBP-473830.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLA2G12A
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Protein Name
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phospholipase A2, group XIIA
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425274
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InnateDB Gene
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IDBG-33929 (PLA2G12A)
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Protein Structure
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Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269PubMed:12522102}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:12522102}. Cytoplasm {ECO:0000269PubMed:12522102}.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010711
Phospholipase A2, group XII secretory
IPR016090
Phospholipase A2 domain
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PFAM |
PF06951
PF00068
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PRINTS |
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PIRSF |
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SMART |
SM00085
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BZM1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
81579
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UniGene |
Hs.389452
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RefSeq |
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HUGO |
HGNC:18554
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OMIM |
611652
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CCDS |
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HPRD |
17858
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IMGT |
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EMBL |
AF306567
AF332892
AY359024
BC017218
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GenPept |
AAG50243
AAG50289
AAH17218
AAQ89383
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