InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANP32A

Summary

InnateDB Protein

IDBP-473909.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANP32A

Protein Name

acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

Synonyms

C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32;

Species

Homo sapiens

Ensembl Protein

ENSP00000417864

InnateDB Gene

IDBG-19082 (ANP32A)

Protein Structure

UniProt Annotation

Function

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. {ECO:0000269PubMed:10400610, ECO:0000269PubMed:11360199, ECO:0000269PubMed:15642345, ECO:0000269PubMed:17557114}.

Subcellular Localization

Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala. {ECO:0000269PubMed:15642345}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0035556	intracellular signal transduction