InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BOC

Summary

InnateDB Protein

IDBP-473947.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BOC

Protein Name

Boc homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418663

InnateDB Gene

IDBG-50192 (BOC)

Protein Structure

UniProt Annotation

Function

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12634428}; Single-pass type I membrane protein {ECO:0000269PubMed:12634428}. Note=Enriched at sites of cell-cell contact.

Disease Associations

Tissue Specificity

Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa. {ECO:0000269PubMed:11782431}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007224	smoothened signaling pathway
GO:0007411	axon guidance
GO:0030030	cell projection organization
GO:0042692	muscle cell differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0051149	positive regulation of muscle cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0044295	axonal growth cone

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BWV1