Version 5.4
Homo sapiens Protein: SPRR2F
Summary
InnateDB Protein IDBP-474155.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRR2F
Protein Name small proline-rich protein 2F
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418193
InnateDB Gene IDBG-409216 (SPRR2F)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008544 epidermis development
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RM1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 6705
UniGene Hs.490252
RefSeq NP_001014450
HUGO HGNC:11266
OMIM
CCDS CCDS30867
HPRD 18699
IMGT
EMBL AF333956 AL139417
GenPept AAK70943 CAI21954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca