Version 5.4
Homo sapiens Protein: PLGRKT
Summary
InnateDB Protein IDBP-47434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLGRKT
Protein Name chromosome 9 open reading frame 46
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000223864
InnateDB Gene IDBG-47432 (PLGRKT)
Protein Structure
UniProt Annotation
Function Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9. {ECO:0000269PubMed:21940822}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21940822}; Multi-pass membrane protein {ECO:0000269PubMed:21940822}. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla. {ECO:0000269PubMed:21795689, ECO:0000269PubMed:21940822}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0010756 positive regulation of plasminogen activation
Cellular Component
GO:0005739 mitochondrion
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR019319 Protein of unknown function DUF2368
PFAM PF10166
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBL7
PhosphoSite PhosphoSite-Q9HBL7
TrEMBL
UniProt Splice Variant
Entrez Gene 55848
UniGene Hs.584242
RefSeq NP_060935
HUGO HGNC:23633
OMIM
CCDS CCDS6463
HPRD 12961
IMGT
EMBL AF220050 AF225420 AK027594 AK312736 AL135786 BC008212 CH471071
GenPept AAF67643 AAG09722 AAH08212 BAB55219 BAG35607 CAH70364 EAW58765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca