Version 5.4
Homo sapiens Protein: RNF185
Summary
InnateDB Protein IDBP-474340.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF185
Protein Name ring finger protein 185
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427755
InnateDB Gene IDBG-4505 (RNF185)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2. {ECO:0000269PubMed:21931693, ECO:0000269PubMed:24019521}.
Subcellular Localization Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006914 autophagy
GO:0016567 protein ubiquitination
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96GF1
PhosphoSite PhosphoSite-Q96GF1
TrEMBL A0A024R1F5
UniProt Splice Variant
Entrez Gene 91445
UniGene Hs.570733
RefSeq
HUGO HGNC:26783
OMIM
CCDS CCDS13890
HPRD 08790
IMGT
EMBL AC002073 AC005005 AK095947 AK291236 BC009504 BC012817 BC026040 BC033166 BC035684 CH471095 CR456349 DQ296559 DQ296561 DQ296562 DQ296565
GenPept AAH09504 AAH12817 AAH26040 AAH33166 AAH35684 ABB97506 ABB97508 ABB97509 ABB97512 BAC04659 BAF83925 CAG30235 EAW59947 EAW59949 EAW59951

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca