Version 5.4
Homo sapiens Protein: ABHD6
Summary
InnateDB Protein IDBP-474368.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABHD6
Protein Name abhydrolase domain containing 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000420315
InnateDB Gene IDBG-42034 (ABHD6)
Protein Structure
UniProt Annotation
Function Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0008152 metabolic process
GO:0030336 negative regulation of cell migration
GO:0060292 long term synaptic depression
GO:2000124 regulation of endocannabinoid signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000073 Alpha/beta hydrolase fold-1
IPR000639 Epoxide hydrolase-like
IPR004142 NDRG
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00561
PF03096
PRINTS PR00111
PR00412
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BV23
PhosphoSite PhosphoSite-Q9BV23
TrEMBL C9JNE7
UniProt Splice Variant
Entrez Gene 57406
UniGene Hs.736139
RefSeq XP_005265391
HUGO HGNC:21398
OMIM
CCDS CCDS2887
HPRD 12407
IMGT
EMBL AC098479 AC137936 AK122983 AK172797 AK313168 BC001698 CH471055
GenPept AAH01698 BAD18771 BAG35986 BAG53832 EAW65360 EAW65361 EAW65362 EAW65365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca