InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGT1A3

Summary

InnateDB Protein

IDBP-474399.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT1A3

Protein Name

UDP glucuronosyltransferase 1 family, polypeptide A3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418532

InnateDB Gene

IDBG-407487 (UGT1A3)

Protein Structure

UniProt Annotation

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269PubMed:18674515}.

Subcellular Localization

Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus. {ECO:0000269PubMed:18004212}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0008194	UDP-glycosyltransferase activity
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008152	metabolic process
GO:0030259	lipid glycosylation
GO:0042573	retinoic acid metabolic process
GO:0052695	cellular glucuronidation
GO:0052696	flavonoid glucuronidation
GO:0052697	xenobiotic glucuronidation