InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ODZ2

Summary

InnateDB Protein

IDBP-474402.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ODZ2

Protein Name

odz, odd Oz/ten-m homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000429430

InnateDB Gene

IDBG-56754 (ODZ2)

Protein Structure

UniProt Annotation

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. {ECO:0000250, ECO:0000269PubMed:21724987}.Isoform 2: Acts as a ligand of the LPHN1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. {ECO:0000269PubMed:21724987}.Ten-2 intracellular domain: Induces gene transcription inhibition. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with LPHN1 across intercellular junctions. {ECO:0000250}.Isoform 2: Cell membrane. Note=Colocalizes with LPHN1 across intercellular junctions.Ten-2 intracellular domain: Nucleus, PML body {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver. {ECO:0000269PubMed:10574461}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007157	heterophilic cell-cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0016337	single organismal cell-cell adhesion
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0051491	positive regulation of filopodium assembly
GO:0097264	self proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane
GO:0016605	PML body
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR006530 YD repeat
IPR008969 Carboxypeptidase-like, regulatory domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR008996 Cytokine, IL-1-like
IPR009471 Teneurin intracellular, N-terminal
IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
IPR013111 EGF-like domain, extracellular
IPR022385 Rhs repeat-associated core

PFAM

PF00008
PF07645
PF05593
PF06484
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NT68