Version 5.4
Homo sapiens Protein: CASP12
Summary
InnateDB Protein IDBP-474500.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP12
Protein Name caspase 12 (gene/pseudogene)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427128
InnateDB Gene IDBG-69532 (CASP12)
Protein Structure
UniProt Annotation
Function Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. {ECO:0000269PubMed:12054529, ECO:0000269PubMed:15129283}.
Subcellular Localization
Disease Associations
Tissue Specificity Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. {ECO:0000269PubMed:12054529}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type
PFAM PF00619
PF00656
PRINTS PR00376
PIRSF PIRSF038001
SMART SM00114
SM00115
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UXS9
PhosphoSite PhosphoSite-Q6UXS9
TrEMBL
UniProt Splice Variant
Entrez Gene 100506742
UniGene Hs.476989
RefSeq NP_001177945
HUGO HGNC:19004
OMIM 608633
CCDS
HPRD
IMGT
EMBL AF464191 AF464192 AF464193 AF464194 AF464195 AF486844 AF486845 AF486846 AF486847 AY358222
GenPept AAQ88589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca