InnateDB Protein
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IDBP-474681.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZFYVE28
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Protein Name
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zinc finger, FYVE domain containing 28
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000426299
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InnateDB Gene
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IDBG-7492 (ZFYVE28)
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Protein Structure
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Function |
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269PubMed:19460345}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:19460345}. Early endosome membrane {ECO:0000269PubMed:19460345}. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007175
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negative regulation of epidermal growth factor-activated receptor activity
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GO:0042059
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negative regulation of epidermal growth factor receptor signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000306
FYVE zinc finger
IPR011011
Zinc finger, FYVE/PHD-type
IPR017455
Zinc finger, FYVE-related
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PFAM |
PF01363
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PRINTS |
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PIRSF |
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SMART |
SM00064
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HCC9
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PhosphoSite |
PhosphoSite-Q9HCC9
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TrEMBL |
Q49AA1
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UniProt Splice Variant |
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Entrez Gene |
57732
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UniGene |
Hs.667172
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RefSeq |
NP_001166130
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HUGO |
HGNC:29334
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OMIM |
614176
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CCDS |
CCDS54708
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HPRD |
11701
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IMGT |
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EMBL |
AB046863
AK126692
AK293775
AK294710
AK294874
AK316484
AL158068
AL645924
BC032605
BC035793
BC041866
BC053664
BC137309
BC137310
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GenPept |
AAH41866
AAH53664
AAI37310
AAI37311
BAB13469
BAG54362
BAH11593
BAH11855
BAH11908
BAH14855
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