Version 5.4
Homo sapiens Protein: EGFLAM
Summary
InnateDB Protein IDBP-474684.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGFLAM
Protein Name EGF-like, fibronectin type III and laminin G domains
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000425579
InnateDB Gene IDBG-17319 (EGFLAM)
Protein Structure
UniProt Annotation
Function Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0030054 cell junction
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR001791 Laminin G domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00054
PF02210
PRINTS
PIRSF
SMART SM00210
SM00282
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q63HQ2
PhosphoSite PhosphoSite-Q63HQ2
TrEMBL D6RJD2
UniProt Splice Variant
Entrez Gene 133584
UniGene Hs.20103
RefSeq
HUGO HGNC:26810
OMIM
CCDS CCDS47199
HPRD 13433
IMGT
EMBL AC010338 AC010351 AC010457 AC091839 AK092479 AK092994 AK096474 AK097549 AK291602 BC031251 BC033177 BC033188 BC063822 BX647551 CH471119
GenPept AAH31251 AAH33177 AAH33188 AAH63822 BAC03900 BAC04013 BAC04800 BAC05096 BAF84291 CAH56137 EAW55968

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca