Version 5.4
Homo sapiens Protein: NSUN4
Summary
InnateDB Protein IDBP-474717.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSUN4
Protein Name NOP2/Sun domain family, member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419740
InnateDB Gene IDBG-98113 (NSUN4)
Protein Structure
UniProt Annotation
Function Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. {ECO:0000269PubMed:21531335, ECO:0000269PubMed:23022348}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:21531335, ECO:0000269PubMed:22949673, ECO:0000269PubMed:23022348}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0032259 methylation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit
Protein Structure and Domains
PDB ID
InterPro IPR001678 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p
IPR023267 RNA (C5-cytosine) methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01189
PRINTS PR02008
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CB9
PhosphoSite PhosphoSite-Q96CB9
TrEMBL
UniProt Splice Variant
Entrez Gene 387338
UniGene Hs.742506
RefSeq NP_950245
HUGO HGNC:31802
OMIM 615394
CCDS CCDS534
HPRD 14842
IMGT
EMBL AK021577 AK057420 AK291741 AK295003 AL122001 BC014441 BC016907 CH471059
GenPept AAH14441 AAH16907 BAB13847 BAF84430 BAG51912 BAG58065 CAI21962 EAX06917

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca