Version 5.4
Homo sapiens Protein: MFN1
Summary
InnateDB Protein IDBP-474859.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFN1
Protein Name mitofusin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419926
InnateDB Gene IDBG-66114 (MFN1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0008053 mitochondrial fusion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001401 Dynamin, GTPase domain
IPR006884 Fzo/mitofusin HR2 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00350
PF04799
PRINTS
PIRSF
SMART SM00053
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H7C5H5
UniProt Splice Variant
Entrez Gene 55669
UniGene Hs.708940
RefSeq
HUGO HGNC:18262
OMIM 608506
CCDS
HPRD 16344
IMGT
EMBL AC007620 AC007823
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca