Version 5.4
Homo sapiens Protein: PYDC2
Summary
InnateDB Protein IDBP-474872.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYDC2
Protein Name pyrin domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000428325
InnateDB Gene IDBG-408825 (PYDC2)
Protein Structure
UniProt Annotation
Function Inhibits NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA. Disrupts the interaction between PYCARD and NLRP3. {ECO:0000269PubMed:17339483}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17339483}. Nucleus {ECO:0000269PubMed:17339483}.
Disease Associations
Tissue Specificity Predominantly expressed in peripheral blood. Weakly expressed in testis. {ECO:0000269PubMed:17339483}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR004020 DAPIN domain
IPR011029 Death-like domain
PFAM PF02758
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q56P42
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 152138
UniGene Hs.690618
RefSeq NP_001076777
HUGO HGNC:33512
OMIM 615701
CCDS
HPRD
IMGT
EMBL AY858112
GenPept AAX54598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca