Version 5.4
Homo sapiens Protein: SPSB2
Summary
InnateDB Protein IDBP-475054.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPSB2
Protein Name splA/ryanodine receptor domain and SOCS box containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000430872
InnateDB Gene IDBG-15460 (SPSB2)
Protein Structure
UniProt Annotation
Function Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:15601820}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001496 SOCS protein, C-terminal
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF07525
PF00622
PRINTS
PIRSF
SMART SM00253
SM00969
SM00449
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99619
PhosphoSite PhosphoSite-Q99619
TrEMBL E5RIC2
UniProt Splice Variant
Entrez Gene 84727
UniGene Hs.670096
RefSeq NP_001139788
HUGO HGNC:29522
OMIM 611658
CCDS CCDS8567
HPRD 13610
IMGT
EMBL AF403027 BC002983 BC071933 CH471116 U47924
GenPept AAB51328 AAH02983 AAH71933 AAL57346 EAW88719 EAW88720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca